TYLENOL [Aetaminophen] metabolism Cyp 3A4 and 2E1: CYP3A4 is the major Cytochrome P 450 [Cyp] enzyme that catalyzes acetaminophen oxidation into NAPQI in human Phase I liver detox. The other Cyp enzyme Napqi hi res stock photography and images Alamy An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance What Are the Potential Sites of Protein Arylation by N Acetyl p benzoquinone Imine (NAPQI)? Chemical Research in Toxicology NAPQI an overview ScienceDirect Topics