Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv FOXO4 DRI Legion inc Development of a novel senolytic by precise disruption of FOXO4 p53 complex eBioMedicine FOXO4 DRI improves spermatogenesis in aged mice through reducing senescence associated secretory phenotype secretion from Leydig cells ScienceDirect 2022 Lupus Highlight Therapeutic Targeting of Senescent Cells in Lupus, Lupus Research Program, Congressionally Directed Medical Research Programs
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foxo4-dri senolytic human trial The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI